1. Adetutu Adebowale#, Jungha Byun#, Jaegwon Chung#, Hyun-Joon Lee, Declan Gresham, Jina Lim, Jae-Kyung Lee*. Adoptive NK cell transfer confers neuroprotection by attenuating neuroinflammation and a-synucelin pathology in a mouse model of synucleinopathy. (#authors equally contributed.) (Molecular Neurodegeneration Advances, 2025, in press)

2. Byrne M, Petramfar P, Lee JK, Smeyne R. (2024) Templating of Monomeric Alpha-Synuclein Induces Inflammation and SNpc Dopamine Neuron Death in a Genetic Mouse Model of Synucleinopathy Res Sq [Preprint]. 2024 Nov 20:rs.3.rs-5269499. doi: 10.21203/rs.3.rs-5269499/v1. PMID: 39606453; PMCID: PMC11601858.

3. Chung J, Jernigan J, Menees K, Lee JK*. (2024) RGS10 mitigates high glucose induced microglial inflammation via reactive oxidative stress pathway and enhances synuclein clearance in microglia Font. Cell. Neurosci., 15 May 2024. Doi:org/10.3389/fncel.2024.1374298

4. Weber S#, Menees KB#, Park J, Agin-Liebes J, Lin CC, Alcalay RN, Lee JK*. (2024) Distinctive blood CD56dim NK cell subset profiles and increased NKG2D expression in NK cells in Parkinson’s disease. NPJ Parkinsons Dis. 2024 Feb 15;10(1):36. doi: 10.1038/s41531-024-00652-y. PubMed PMID: 38360903; PubMed Central PMCID: PMC10869354.

5. Menees K, Lee JK*. New Insights and Implications of NK cells in Parkinson's disease. Journal of Parkinson's disease. (2022) Doi:10.3233/JPD-223212

6. Almurairi F, Sarr D, Tucker S, Fantone K, Lee JK, Rada B. RGS10 reduces lethal influenza infection and associated lung inflammation in mice. Front. Immunol., 29 November (2021) https://doi.org/10.3389/fimmu.2021.77228

7. Menees K#, Earls RH#, Chung J, Jernigan J, Lee JK*. Age-related changes in immune cells may influence risk for age-related degeneration. Immun Ageing 18, 3 (2021). https://doi.org/10.1186/s12979-021-00214-3.

8. Earls RH, Lee JK*. (2020) The role of natural killer cells in Parkinson’s disease. Experimental Molecular Medicine, Review, doi.org/10.1038/s12276-020-00505-7.

9. Almutairi FA, Lee JK, Rada B. (2020) Regulator of G-protein signaling 10: structure, expression and functions in physiology and disease, Review. Cell Signal. 2020 Aug 31:109765. doi: 10.1016/j.cellsig.2020.109765. PubMed PMID: 32882407.

10. Schank J, Schroeder J, Lee S, Chang J, Li JM, Jin Z, Birnir B, Chung J, Lee JK, Aalkjaer C, Boedtkjer E and Choi I. (2020) Increased alcohol consumption in mice lacking sodium bicarbonate transporter NBCn1. Sci Rep. 2020 Jul 3;10(1):11017. doi: 10.1038/s41598-020-67291-0. PubMed PMID: 32620847; PubMed Central PMCID: PMC7335059.

11. Earls RH#, Menees KB#, Chung J#, Gutekunst CA, Lee HJ, Hazim MG, Rada B, Wood LB, Lee JK* (2020) NK cells clear α-synuclein and the depletion of NK cells exacerbates synuclein pathology in a mouse model of α-synucleinopathy. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1762-1771. doi: 10.1073/pnas.1909110117. Epub 2020 Jan 3. PubMed PMID: 31900358; PubMed Central PMCID: PMC6983411.

12. Earls RH, Menees KB, Chung J, Barber J, Gutekunst CA, Hazim MG, Lee JK* (2019) Intracerebral injection of pre-formed alpha-synuclein fibrils alters central and peripheral immune cell profiles in mice. Journal of Neuroinflammation. 2019 Dec 3;16(1):250. doi: 10.1186/s12974-019-1636-8. PubMed PMID: 31796095; PubMed Central PMCID: PMC6889316. *Corresponding author

13. Shao Q, Yang M, Liang C, Ma L, Zhang W, Lee JK, Liang C, Chen JF (2019) c9orf72 and smcr8 mutant mice reveal MTORC1 activation due to impaired lysosomal degradation and exocytosis. Autophagy. 2019 Dec 26;1-16. doi: 10.1080/15548627.2019.1703353. PMID: 31847700.

14. Fang X., Chung J, Olsen E., Snider I, Earls RH, Jeon J. Park HJ, Lee JK* (2018) RGS10 depletion exaggerates high-fat diet induced-insulin resistance and inflammation in mice that mitigated by green tea extract. Nutritional Research 2019 Oct;70:50-59. doi: 10.1016/j.nutres.2018.06.004. Epub 2018 Jun 28. PubMed PMID: 30032988. *Corresponding author

15. Lee JK*, Bou Dagher J. (2016) Regulator of G-protein Signaling (RGS) 1 and RGS 10 proteins as potential drug targets for neuroinflammatory and neurodegenerative diseases. AAPS Journal 2016 May;18(3):545-9. doi: 10.1208/s12248-016-9883-4. Epub 2016 Feb 22. PubMed PMID: 26902301; PubMed Central PMCID: PMC5256602. *Corresponding author (Review)

16. Lee JK*, Kannarkat G, Chung JG, Lee HJ, Graham KG, Tansey MG (2016) RGS10 deficiency ameliorates the severity of disease in experimental autoimmune encephalitis. Journal of Neuroinflammation 2016 Feb 1;13:24. doi: 10.1186/s12974-016-0491-0. PubMed PMID: 26831924; PubMed Central PMCID: PMC4736282. *Corresponding author

17. Won S, Lee JK, Stein D. (2015) Recombinant tissue plasminogen activator promotes, and progesterone attenuates, microglia/macrophage M1 polarization and recruitment of microglia after MCAO stroke in rats. Brain, Behavior, and Immunity 2015 Oct;49:267-79. doi: 10.1016/j.bbi.2015.06.007. Epub 2015 Jun 17. PubMed PMID: 26093305.

18. Tansey MG, Lee JK. (2015) Inflammation in Nervous System Disorders: Introduction. Neuroscience 2015 Aug 27;302:1. doi: 10.1016/j.neuroscience.2015.05.006. Epub 2015 May 16. PubMed PMID: 25988757.

19. Lee JK* and Tansey MG (2015) Physiology of RGS10 in neurons and immune cells. Progress in Molecular Biology and Translational Science. 2015;133:153-67. doi: 10.1016/bs.pmbts.2015.01.005. Epub 2015 Apr 1. Review. PubMed PMID: 26123306.

20. Kannarkat G, Lee JK, Ramsey C, Chung J, Chang J, Liu X, Oliver D, Shepherd K, Tansey MG (2015) Age-related changes in RGS10 expression in peripheral immune cells but not in the midbrain may influence risk for age-related degeneration. Neurobiology of Aging, 2015 May;36(5):1982-93. doi: 10.1016/j.neurobiolaging.2015.02.006. Epub 2015 Feb 13. PubMed PMID: 25784210; PubMed Central PMCID: PMC4417042. 

21. Kannarkat GT, Cook DA, Lee JK, Chang J, Chung J, Sandy, E, Sperin EM, Factor S, Boss JM and Tansey MG (2015) Common Genetic Variant Association with Altered HLA Expression, Synergy with Pyrethroid Exposure, and Risk for Parkinson's Disease: An Observational and Case-Control Study. NPJ Parkinson’s Disease 2015;1. doi: 10.1038/npjparkd.2015.2. Epub 2015 Apr 22. PubMed PMID: 27148593; PubMed Central PMCID: PMC4853162.

22. Lee JK*, Tansey MG. (2013) Microglia isolation from adult mouse brain. Methods in Molecular Biology, 2013;1041:17-23. doi: 10.1007/978-1-62703-520-0_3. PubMed PMID: 23813365; PubMed Central PMCID: PMC4145600.

23. Lee JK*, Chung J, Druey K, Tansey MG*. (2012) Neuroprotective role of RGS10 in dopaminergic neuronal through PKA/cAMP-response element binding protein (CREB) pathway.  Journal of Neurochemistry, 2012 Jul;122(2):333-43. doi: 10.1111/j.1471-4159.2012.07780.x. Epub 2012 May 30. PubMed PMID: 22564151; PubMed Central PMCID: PMC3435458.

24. Harms AS, Lee JK, Nguyen TA, Chang J, Ruhn KM, Treviño I, Tansey MG. (2012) Regulation of Microglia Effector Functions by Tumor Necrosis Factor (TNF): implications for anti-TNF therapy in the CNS. Glia 2012 Feb;60(2):189-202. doi: 10.1002/glia.21254. Epub 2011 Oct 11. PubMed PMID: 21989628; PubMed Central PMCID: PMC3232308.

25. Lee JK, Chung J, McAlpine FE, Tansey MG. (2011) Regulator of G-protein Signaling-10 negatively regulates NF-kB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats. Journal of Neuroscience, 2011 Aug 17;31(33):11879-88. doi: 10.1523/JNEUROSCI.1002-11.2011. PubMed PMID: 21849548; PubMed Central PMCID: PMC3326398.

26. Tran T, Nguyen AD, Chang JJ, Goldberg MS, Lee JK*, Tansey MG*. (2011) Lipopolysaccharide and Tumor Necrosis Factor regulate Parkin expression via Nuclear Factor-Kappa B. PLoS One, 2011;6(8):e23660. doi: 10.1371/journal.pone.0023660. Epub 2011 Aug 17. PubMed PMID: 21858193; PubMed Central PMCID: PMC3157435. 

27. Lee JK, Tran T, Tansey MG. (2009) Microglia and Neuroinflammation in Parkinson’s disease. Journal of Neuroimmune Pharmacology, 2009 Dec;4(4):419-29. doi: 10.1007/s11481-009-9176-0. Epub 2009 Oct 10. Review. PubMed PMID: 19821032; PubMed Central PMCID: PMC3736976.

28. McAlpine FE, Lee JK, Harms AS, Ruhn KA, Hong J, Das P, Golde TE, LaFerla FM, Oddo S, Blesch A, Tansey MG. (2009) Inhibition of soluble TNF signaling in a mouse model of Alzheimer's disease prevents early amyloid-associated neuropathology. Neurobiology of Disease, 2009 Apr;34(1):163-77. doi: 10.1016/j.nbd.2009.01.006. PubMed PMID: 19320056; PubMed Central PMCID: PMC2948857.

29. Lee JK, McCoy MK, Harms AS, Ruhn KA, Gold SJ, Tansey MG (2008). Regulator of G-protein signaling-10 (RGS10) promotes dopaminergic neuron survival via regulation of the microglial inflammatory response. Journal of Neuroscience, 2008 Aug 20;28(34):8517-28. doi: 10.1523/JNEUROSCI.1806-08.2008. PubMed PMID: 18716210; PubMed Central PMCID: PMC2739568.

30. Tansey MG, Frank-Cannon TC, McCoy MK, Lee JK, Martinez TN, McAlpine FE, Ruhn KA, Tran TA. (2008) Neuroinflammation in Parkinson’s disease: Is there sufficient evidence for mechanism-based interventional therapy? Frontiers in Bioscience Jan 1;13:709-17. doi: 10.2741/2713. Review. PubMed PMID: 17981581

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Full publication lists can be found:

https://www.ncbi.nlm.nih.gov/myncbi/jae%20kyung.lee.1/bibliography/public/

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